Abstract Background The emergence of next-generation sequencing (NGS) marked a revolution in biological research, enabling comprehensive characterization of the transcriptome and detailed analysis of the epigenome landscape.This technology has made it possible to detect differences across cell types, genotypes, and conditions.Advances in short-read
Both D1R and D2R knock out (KO) mice of the major dopamine receptors show significant motor impairments.However, there are some discrepant reports, which may be due to the differences in genetic background and experimental procedures.In addition, only few studies directly compared the motor performance of D1R Gardening Socks and D2R KO mice.In this
Effective communication is essential to the practice of pediatric oncology.Clear and empathic delivery of diagnostic and prognostic information positively impacts the ways in which patients and families Ear Putty cope.Honest, compassionate discussions regarding goals of care and hopes for patients approaching end of life can provide healing when ot
Trimethylamine N-oxide (TMAO) is a biologically active gut microbiome-derived dietary metabolite.Recent studies have shown that high circulating plasma TMAO levels are closely associated with diseases such as atherosclerosis and hypertension, and metabolic disorders such as diabetes and hyperlipidemia, contributing to endothelial dysfunction.There
Cadherin 23 (CDH23), a component of tip links in hair cells of vertebrate animals, is essential to mechanotransduction by hair cells in the inner ear.A homolog of CDH23 occurs in hair bundles of Kitchen sea anemones.Anemone hair bundles are located on the tentacles where they detect the swimming movements of nearby prey.The anemone CDH23 is predict